41BB ligand (41BBL; also CD137L) is a 32 kDa type II transmembrane protein that belongs
to the TNF superfamily (TNFSF) molecules. The human 41BBL cDNA encodes a 254 amino
acid (aa) protein that contains a 25 aa N-terminal cytoplasmic domain, a 23 aa transmembrane
segment, and a 206 aa C-terminal extracellular region. The extracellular domain (ECD) of 41BBL has a jellyroll, β-sandwich tertiary structure that is similar to other TNFSF
members. There is onlyone cysteine in the human ECD, and no potential Nlinked glycosylation
sites.
原厂资料:
41BB ligand (41BBL; also CD137L) is a 32 kDa type II transmembrane protein that belongs
to the TNF superfamily (TNFSF) molecules. The human 41BBL cDNA encodes a 254 amino
acid (aa) protein that contains a 25 aa N-terminal cytoplasmic domain, a 23 aa transmembrane
segment, and a 206 aa C-terminal extracellular region. The extracellular domain (ECD) of 41BBL has a jellyroll, β-sandwich tertiary structure that is similar to other TNFSF
members. There is onlyone cysteine in the human ECD, and no potential Nlinked glycosylation