描述：
Fibroblast growth factor 12 (FGF-12) is a member of the FGF superfamily of molecules which
contains at least 22 members. The FGFs are characterized by the presence of a core, 120
amino acid (aa) βtrefoil structure, and all apparently bind heparin (1, 2). FGF-11, -12, -13,
-14, originally termed FGF homologous factors (FHF) -3, -1, -2, -4, respectively, form a subgroup
within the FGF family. Human FGF-12/FHF-1 is synthesized as a 243 aa protein. It lacks a typical
signal sequence and is considered to be a cytoplasmic protein. It does, however, possess an
Nterminal bipartite nuclear localization signal (NLS) at aa 11 -18 and 28 -38.The 243 aa
protein has at least one alternate splice form that is 181 aa in length. This is termed FGF-12B.
Alternate splicing deletes the N-terminal 66 aa in FGF-12 and replaces them with four aa in
FGF-12B. This substitution removes the NLS from the short form. Studies on the short form
(12B) show that it cannot bind any of the common FGF receptors. This is consistent with its
cytoplasmic localization. It can, however, bind to IB2 (islet brain-2), a cellular kinase scaffold
protein, and voltagegated sodium channels, suggesting FGF-12B plays an important role in
intracellular signaling and ion exchange. Mouse and human FGF-12B differ by only one amino
acid.
原厂资料：
Fibroblast growth factor 12 (FGF-12) is a member of the FGF superfamily of molecules which
contains at least 22 members. The FGFs are characterized by the presence of a core, 120
amino acid (aa) βtrefoil structure, and all apparently bind heparin (1, 2). FGF-11, -12, -13,
-14, originally termed FGF homologous factors (FHF) -3, -1, -2, -4, respectively, form a subgroup
within the FGF family. Human FGF-12/FHF-1 is synthesized as a 243 aa protein. It lacks a typical
signal sequence and is considered to be a cytoplasmic protein. It does, however, possess an
Nterminal bipartite nuclear localization signal (NLS) at aa 11 -18 and 28 -38.The 243 aa
protein has at least one alternate splice form that is 181 aa in length. This is termed FGF-12B.
Alternate splicing deletes the N-terminal 66 aa in FGF-12 and replaces them with four aa in
FGF-12B. This substitution removes the NLS from the short form. Studies on the short form
(12B) show that it cannot bind any of the common FGF receptors. This is consistent with its
cytoplasmic localization. It can, however, bind to IB2 (islet brain-2), a cellular kinase scaffold
protein, and voltagegated sodium channels, suggesting FGF-12B plays an important role in
intracellular signaling and ion exchange. Mouse and human FGF-12B differ by only one amino
acid.
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