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描述:
Plateletderived growth factor (PDGF) was discovered as a major mitogenic factor present
in serum but absent from plasma. It was found to be secreted from the α-granules of
platelets ctivated during the coagulation of blood to form serum. Subsequent studies have
demonstrated that PDGF is not one molecule but three, each a dimeric combination of two
distinct but structurally related peptide chains designated A and B. The dimeric isoforms
PDGF-AA, AB and BB are differentially expressed in various cell types and their effects are
mediated through two distinct receptors, termed α and β.
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