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描述:
Fas, also known as APO-1 or CD95, belongs to the death receptor subfamily of the TNF
receptor superfamily and is designated TNFRSF6. Rat Fas cDNA encodes 324 amino acids (aa)
that include a 21 aa signal peptide, a 150 aa extracellular domain (ECD) that contains three
cysteine-rich TNFR repeats, a 17 aa transmembrane sequence, and a 136 aa cytoplasmic
domain containing a death domain (DD), which is required for transducing apoptotic signals.
Mature rat Fas ECD shares 68% aa sequence identity with mouse Fas, and 56 -58% with human,
feline, bovine and porcine Fas. A 114 aa potential rat Fas isoform contains an alternate start site
at aa 211, thus lacking all three TNFR repeats.
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