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描述:
B-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a 32 kDa
transmembrane glycoprotein in the TNF ligand superfamily. It is involved in multiple aspects
of immune system regulation, particularly towards B cells. Mature human BAFF consists of a 46
amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 218 aa extracellular
domain (ECD) with a stalk region and one TNF-like domain. Within aa 134-285 of the ECD,
human BAFF shares 72% aa sequence identity with mouse BAFF. It can be expressed as a
homotrimer or as a heteromer in association with the related TNFSF member APRIL.
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