Galectins are a family of carbohydratebinding proteins with specificity for N-acetyllactosaminecontaining glycoproteins. At least 14 mammalian galectins share structural similarities in their
carbohydrate recognition domains (CRD), forming three groups often termed prototype (one CRD),
tandemrepeat (two CRDs) and chimeric (one CRD, unique N-terminus). All lack classical signal
peptides, but are present and active both within and outside of the cell. Galectins are involved
in cell adhesion, migration, survival and apoptosis, and are often up or downregulated in cancer.
原厂资料：
Galectins are a family of carbohydratebinding proteins with specificity for N-acetyllactosaminecontaining glycoproteins. At least 14 mammalian galectins share structural similarities in their
carbohydrate recognition domains (CRD), forming three groups often termed prototype (one CRD),
tandemrepeat (two CRDs) and chimeric (one CRD, unique N-terminus). All lack classical signal
peptides, but are present and active both within and outside of the cell. Galectins are involved
in cell adhesion, migration, survival and apoptosis, and are often up or downregulated in cancer.
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