描述：
FGF basic is a member of the FGF family, currently comprised of 23 related mitogenic proteins
which show 35-60% amino acid conservation. FGF acidic and basic, unlike the other members
of the family, lack signal peptides and are apparently secreted by mechanisms other than the
classical protein secretion pathway. FGF basic has been isolated from a number of sources,
including neural tissue, pituitary, adrenal cortex, corpus luteum and placenta. This factor
contains four cysteine residues but reduced FGF basic retains full biological activity, indicating
that disulfide bonds are not required for this activity. Several reports indicate that a variety
of forms of FGF basic are produced as a result of N-terminal extensions. These extensions
apparently affect localization of FGF basic in cellular compartments but do not affect biological
activity. Studies indicate that binding of FGF to heparin or cell surface heparan sulfate
proteoglycans is necessary for binding of FGF to high affinity FGF receptors. FGF acidic and
basic appear to bind to the same high affinity receptors and show a similar range of biological
activities.FGF basic stimulates the proliferation of all cells of mesodermal origin, and many cells
of neuroectodermal, ectodermal and endodermal origin. The cells include fibroblasts,
endothelial cells, astrocytes, oligodendrocytes, neuroblasts, keratinocytes, osteoblasts, smooth
muscle cells, and melanocytes. FGF basic is chemotactic and mitogenic for endothelial cells in
vitro. FGF basic induces neuron differentiation, survival and regeneration. FGF basic has also
been shown to be crucial in modulating embryonic development and differentiation. These
observed in vitro functions of FGF basic suggest FGF basic may play a role in vivo in the
modulation of such normal processes as angiogenesis, wound healing and tissue repair,
embryonic development and differentiation, and neuronal function and neural degeneration.
Additionally, FGF basic may participate in the production of a variety of pathological conditions
resulting from excessive cell proliferation and excessive angiogenesis.
原厂资料：
FGF basic is a member of the FGF family, currently comprised of 23 related mitogenic proteins
which show 35-60% amino acid conservation. FGF acidic and basic, unlike the other members
of the family, lack signal peptides and are apparently secreted by mechanisms other than the
classical protein secretion pathway. FGF basic has been isolated from a number of sources,
including neural tissue, pituitary, adrenal cortex, corpus luteum and placenta. This factor
contains four cysteine residues but reduced FGF basic retains full biological activity, indicating
that disulfide bonds are not required for this activity. Several reports indicate that a variety
of forms of FGF basic are produced as a result of N-terminal extensions. These extensions
apparently affect localization of FGF basic in cellular compartments but do not affect biological
activity. Studies indicate that binding of FGF to heparin or cell surface heparan sulfate
proteoglycans is necessary for binding of FGF to high affinity FGF receptors. FGF acidic and
basic appear to bind to the same high affinity receptors and show a similar range of biological
activities.FGF basic stimulates the proliferation of all cells of mesodermal origin, and many cells
of neuroectodermal, ectodermal and endodermal origin. The cells include fibroblasts,
endothelial cells, astrocytes, oligodendrocytes, neuroblasts, keratinocytes, osteoblasts, smooth
muscle cells, and melanocytes. FGF basic is chemotactic and mitogenic for endothelial cells in
vitro. FGF basic induces neuron differentiation, survival and regeneration. FGF basic has also
been shown to be crucial in modulating embryonic development and differentiation. These
observed in vitro functions of FGF basic suggest FGF basic may play a role in vivo in the
modulation of such normal processes as angiogenesis, wound healing and tissue repair,
embryonic development and differentiation, and neuronal function and neural degeneration.
Additionally, FGF basic may participate in the production of a variety of pathological conditions
resulting from excessive cell proliferation and excessive angiogenesis.
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