描述：
Growth and differentiation factorassociated serum protein-1 (GASP-1) was isolated in a
screen to identify proteins in mice that copurify with myostatin (GDF-8), a potent negative
regulator of skeletal muscle mass. The GASP-1 cDNA encodes a 571 amino acid protein that
contains a 29 amino acid signal sequence and is comprised of many conserved domains: WAP,
follistatin/Kazal, immunoglobulin, two tandem Kunitz, and netrin. Two related human proteins
which contain the same domain structure are called WFIKKN (based on the presence and
order of these conserved domains) and WFIKKNRP (WFIKKN-related protein). Mouse GASP1
is homologous to human WFIKKNRP and mouse GASP-2 to human WFIKKN. Human GASP-1 is
the same protein as WFIKKNRP. WAP, follistatin, Kazal and netrin domains are all implicated in
protease inhibition, and these proteins may be multivalent protease inhibitors. GASP-1 and-2
show distinct expression patterns both in the developing fetus and the adult. In the developing
fetus, GASP-1 expression is highest in the brain, skeletal muscle, thymus and kidney while
GASP2 is abundant in the lung, skeletal muscle and liver. In the adult, GASP-1 is primarily
expressed in the ovary, testis, and brain while GASP-2 is in the pancreas, liver, and thymus.
GASP-1 inhibits myostatin and the highly related protein, GDF-11, but not Activin or TGF-β in
vitro . In addition, GASP-1 binds directly but independently to both mature myostatin and the
myostatin propeptide. By amino acid sequence, human GASP-1 is 90% and 55% identical to
mouse GASP-1 and human GASP-2, respectively.
原厂资料：
Growth and differentiation factorassociated serum protein-1 (GASP-1) was isolated in a
screen to identify proteins in mice that copurify with myostatin (GDF-8), a potent negative
regulator of skeletal muscle mass. The GASP-1 cDNA encodes a 571 amino acid protein that
contains a 29 amino acid signal sequence and is comprised of many conserved domains: WAP,
follistatin/Kazal, immunoglobulin, two tandem Kunitz, and netrin. Two related human proteins
which contain the same domain structure are called WFIKKN (based on the presence and
order of these conserved domains) and WFIKKNRP (WFIKKN-related protein). Mouse GASP1
is homologous to human WFIKKNRP and mouse GASP-2 to human WFIKKN. Human GASP-1 is
the same protein as WFIKKNRP. WAP, follistatin, Kazal and netrin domains are all implicated in
protease inhibition, and these proteins may be multivalent protease inhibitors. GASP-1 and-2
show distinct expression patterns both in the developing fetus and the adult. In the developing
fetus, GASP-1 expression is highest in the brain, skeletal muscle, thymus and kidney while
GASP2 is abundant in the lung, skeletal muscle and liver. In the adult, GASP-1 is primarily
expressed in the ovary, testis, and brain while GASP-2 is in the pancreas, liver, and thymus.
GASP-1 inhibits myostatin and the highly related protein, GDF-11, but not Activin or TGF-β in
vitro . In addition, GASP-1 binds directly but independently to both mature myostatin and the
myostatin propeptide. By amino acid sequence, human GASP-1 is 90% and 55% identical to
mouse GASP-1 and human GASP-2, respectively.
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