描述：
The fibroblast growth factor (FGF) family consists of twenty three known structurallyrelated
proteins that play key roles in development, morphogenesis, angiogenesis, wound healing and
tumorigenesis. All FGFs share a common structural fold, the β-trefoil scaffold, in a conserved
central region of approximately 120 amino acid (aa), which contains the active site and a
heparin binding site. FGF-7, also known as keratinocyte growth factor (KGF), was originally
identified from the conditioned medium of a human embryonic lung fibroblast cell line. It is
secreted by cells of mesenchymal origin and functions predominantly on epithelial cells. The
mature caFGF-7 is generated from a 194 aa precursor protein by cleavage of the first 31 aa at
the N-terminus. It shares 97.4% and 95.9% sequence identity with human and mouse KGF,
respectively. FGFs signal through high affinity tyrosine kinase receptors (FGF R). Cellular
responses to FGFs are modulated by heparan sulfate proteoglycans that are also known as
low affinity FGF receptors and by heparin. Various isoforms of the four FGF R exist (FGF R-1
through -4). They are produced from alternatively spliced transcripts in both the extracellular
and intracellular domains. FGF-7 signals through the FGF R2IIIb (also known as KGF R), which
is a spliced variant of FGF R2. KGF R binds FGF-1 and FGF-7 with high affinity and FGF-2 with
a 20-fold lower affinity.
原厂资料：
The fibroblast growth factor (FGF) family consists of twenty three known structurallyrelated
proteins that play key roles in development, morphogenesis, angiogenesis, wound healing and
tumorigenesis. All FGFs share a common structural fold, the β-trefoil scaffold, in a conserved
central region of approximately 120 amino acid (aa), which contains the active site and a
heparin binding site. FGF-7, also known as keratinocyte growth factor (KGF), was originally
identified from the conditioned medium of a human embryonic lung fibroblast cell line. It is
secreted by cells of mesenchymal origin and functions predominantly on epithelial cells. The
mature caFGF-7 is generated from a 194 aa precursor protein by cleavage of the first 31 aa at
the N-terminus. It shares 97.4% and 95.9% sequence identity with human and mouse KGF,
respectively. FGFs signal through high affinity tyrosine kinase receptors (FGF R). Cellular
responses to FGFs are modulated by heparan sulfate proteoglycans that are also known as
low affinity FGF receptors and by heparin. Various isoforms of the four FGF R exist (FGF R-1
through -4). They are produced from alternatively spliced transcripts in both the extracellular
and intracellular domains. FGF-7 signals through the FGF R2IIIb (also known as KGF R), which
is a spliced variant of FGF R2. KGF R binds FGF-1 and FGF-7 with high affinity and FGF-2 with
a 20-fold lower affinity.
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