BCMA, B cell maturation, is a member of the TNF receptor superfamily. It has been designated
TNFRSF17. BCMA is a type III membrane protein containing one extracellular cysteine rich
domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have
both been shown to bind to APRIL and BAFF,members of the TNF ligand superfamily. BCMA
expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment.
The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in
peripheral blood B cells and increase the survival of cultured B cells. This data suggests that
BCMA may play an important role in B cell development, function and regulation. Human BCMA
is a 184 amino acid (aa) protein consisting of a 54 aa extracellular domain, a 23 aa
transmembrane domain, and a 107 aa intracellular domain. Mouse and human BCMA share
62% amino acid identity.
原厂资料：
BCMA, B cell maturation, is a member of the TNF receptor superfamily. It has been designated
TNFRSF17. BCMA is a type III membrane protein containing one extracellular cysteine rich
domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have
both been shown to bind to APRIL and BAFF,members of the TNF ligand superfamily. BCMA
expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment.
The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in
peripheral blood B cells and increase the survival of cultured B cells. This data suggests that
BCMA may play an important role in B cell development, function and regulation. Human BCMA
is a 184 amino acid (aa) protein consisting of a 54 aa extracellular domain, a 23 aa
transmembrane domain, and a 107 aa intracellular domain. Mouse and human BCMA share
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