Recombinant Human BMP-1/PCP Protein, CF (10 UG)

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at ambient temperature

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描述：

Bone morphogenetic protein 1 (BMP-1), also known as procollagen C-proteinase (PCP), is a

zinc protease of the astacin family. BMP-1/PCP plays a key role in formation of extracellular

matrix (ECM) by converting precursor proteins into their mature and functional forms. The

precursor proteins identified as substrates for BMP-1/PCP include collagens, biglycan, laminin

5, dentin matrix protein1, and lysyl oxidase.There are six alternatively spliced forms known to

be derived from the BMP-1 gene, and isoform 1 consisting of residues 1 to 730 was expressed.

The secreted and purified protein does not contain the signal peptide (amino acid residues 1-

22) and pro domain (residues 23-120), but contain protease (residues 121-321), CUB I (residues

322-434), CUB II (residues 435-546), EGFlike (residues 547-588) and CUB III (residues 591-703)

domains. The pro domain is apparently cleaved by a furin-like proprotein convertase. The

purified BMP-1/PCP is an active protease and its peptidase activity can be determined as

described above. The purified BMP-1/PCP is predicted to possess procollagen C-proteinase

activity because it contains the minimal domain structure required.

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