描述：
Canine MCP-1 (monocyte chemotactic protein-1) is an 8 kDa member of the CC chemokine
family of chemotactic factors. It is synthesized as a 101 amino acid (aa) precursor that contains
a 23 aa signal sequence and a 78 aa mature segment. It contains no potential N-linked
glycosylation sites and is not known for any posttranslational modifications. Based on human
studies, MCP-1 will primarily circulate as a monomer. Noncovalent dimers are likely to be
found, however. MCP-1 activity has been localized to the Nterminus. Cell types known to
secrete MCP-1 are considerable in number, and include keratinocytes, fibroblasts, endothelium,
osteoblasts, macrophages, mast cells, smooth muscle cells and astrocytes. In the mature MCP-1
segment, there is 82% and 83% aa identity, canine to human and porcine MCP-1, respectively.
When mature canine MCP-1 is compared to (125 aa) extended rodent MCP-1, there is 55% and
56% aa identity, canine to mouse and rat MCP-1, respectively. MCP-1 has three possible
receptors. The first two are CCR2 and CCR11. The third receptor has only been identified in
mice and is called L-CCR (5). Its function is unknown. MCP-1 is best known as a chemotactic
agent for mononuclear cells. It also, however, induces enzyme and cytokine release in monocytes, NK cells, and lymphocytes and histamine release by basophils. Additionally, it is believed to
reduce IL-12 production by dendritic cells and promote a Th2 phenotype in CD4+ T cells.
原厂资料：
Canine MCP-1 (monocyte chemotactic protein-1) is an 8 kDa member of the CC chemokine
family of chemotactic factors. It is synthesized as a 101 amino acid (aa) precursor that contains
a 23 aa signal sequence and a 78 aa mature segment. It contains no potential N-linked
glycosylation sites and is not known for any posttranslational modifications. Based on human
studies, MCP-1 will primarily circulate as a monomer. Noncovalent dimers are likely to be
found, however. MCP-1 activity has been localized to the Nterminus. Cell types known to
secrete MCP-1 are considerable in number, and include keratinocytes, fibroblasts, endothelium,
osteoblasts, macrophages, mast cells, smooth muscle cells and astrocytes. In the mature MCP-1
segment, there is 82% and 83% aa identity, canine to human and porcine MCP-1, respectively.
When mature canine MCP-1 is compared to (125 aa) extended rodent MCP-1, there is 55% and
56% aa identity, canine to mouse and rat MCP-1, respectively. MCP-1 has three possible
receptors. The first two are CCR2 and CCR11. The third receptor has only been identified in
mice and is called L-CCR (5). Its function is unknown. MCP-1 is best known as a chemotactic
agent for mononuclear cells. It also, however, induces enzyme and cytokine release in monocytes, NK cells, and lymphocytes and histamine release by basophils. Additionally, it is believed to
reduce IL-12 production by dendritic cells and promote a Th2 phenotype in CD4+ T cells.
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