Recombinant Mouse WISP-1/CCN4 Protein, CF (50 UG)

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at ambient temperature

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描述：

Mouse WISP-1 (Wnt-induced secreted protein-1; also named CNN4) is a 40 kDa, secreted,

heparinbinding glycoprotein that is a member of the CCN (or CTGF/Cyr61/Nov) cysteine-rich

protein family. It is synthesized as a 367 amino acid (aa) precursor that contains a series of

structural homology modules. Following a 22 aa signal sequence, there is a 68 aa IGFBP-like

domain (aa 53-120), a 66 aa von Willebrand factor type C (VWC) module (aa 121-186), a 41

aa TSP type I domain (aa 220-260) and a 75 aa, Cterminal cysteine knot motif (aa 273-347).

The VWC module is associated with protein-protein interaction, the TSP domain binds sulfated

glycoconjugates, and the cysteine knot mediates dimerization and receptor binding. It is likely

that WISP-1 normally circulates as an 80 kDa homodimer. Multiple splice forms are reported

for human WISP-1, but none for rodent. Mature mouse WISP-1 is 98%, 84% and 85% aa

identical to rat, canine and human WISP-1, respectively. WISP-1 is expressed by fibroblasts

and osteoblasts, and may contribute to fracture healing by promoting bone cell formation.

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