Recombinant Human FGF-BP Protein, CF (25 UG)

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at ambient temperature

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描述：

Fibroblast growth factor binding protein (FGF-BP), also known as HBp17, is a secreted

glycoprotein that increases the bioavailability of FGFs. Mature FGFBP is a 34 kDa, 211

amino acid (aa) O-glycosylated protein with five conserved intrachain disulfide bonds.

FGF-BP contains a heparinbinding domain (aa 110-143) and a distinct FGFbinding region

(aa 193-243). Mature human FGF-BP shares 59% and 54% aa sequence identity with mouse

and rat FGF-BP, respectively. FGF-BP is expressed throughout development and in adult

squamous epithelium. It is upregulated in injured skin, renal tubular epithelium, and spinal

nerves as well as in carcinomas of the skin, colon, and pancreas. FGF-BP binds FGF-1, -2, -7,

-10, and -22 which are secreted and sequestered in the extracellular matrix (ECM) .The

association of FGF-BP with heparan sulfate proteoglycans (HSPG) weakens HSPG attachment

of FGFs and promotes their release. FGF-BP enhances the mitogenic effects of FGFs, thereby

contributing to epithelial, endothelial, and neuronal tissue repair, angiogenesis, and tumor

growth.

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