描述：
HCC-1 (Hemofiltrate CC Chemokine-1) was originally isolated from the hemofiltrate of human
patients with chronic renal failure. It belongs to the CC chemokine superfamily and has been
designated CCL14a. HCC-1/CCL14a cDNA encodes a 93 amino acid (aa) residue precursor with
a 19 aa signal peptide that is cleaved to form the 74 aa mature secreted proprotein. By
alternative splicing, a second longer isoform named HCC-3/CCL14b, which includes sequences
from exon 3, also exists. HCC-1/CCL14a is expressed constitutively in various normal tissues
including spleen, liver, muscle, gut and bone marrow. It circulates at nanomolar concentrations
in human plasma. Different posttranslationally modified HCC-1/CCL14a, including
Oglycosylated and Nterminally truncated variants of HCC-1/CCL14a, have been identified.
Whereas the 74 aa mature propeptide is a weak CCR1 agonist, the proteolytically processed
truncated HCC-1/CCL14a (aa 28 93) is a highly potent agonist of CCR1, CCR5 and to a lesser
extent, CCR3. HCC-1/CCL14a (aa 28 93) promotes chemotaxis of T lymphocytes, monocytes
and eosinophils, and inhibits infection of Mtropic human immunodeficiency virus type 1.
Activation of the HCC-1/CCL14a propeptide to active peptide is mediated by the urokinase
type plasminogen activator or plasmin.
原厂资料：
HCC-1 (Hemofiltrate CC Chemokine-1) was originally isolated from the hemofiltrate of human
patients with chronic renal failure. It belongs to the CC chemokine superfamily and has been
designated CCL14a. HCC-1/CCL14a cDNA encodes a 93 amino acid (aa) residue precursor with
a 19 aa signal peptide that is cleaved to form the 74 aa mature secreted proprotein. By
alternative splicing, a second longer isoform named HCC-3/CCL14b, which includes sequences
from exon 3, also exists. HCC-1/CCL14a is expressed constitutively in various normal tissues
including spleen, liver, muscle, gut and bone marrow. It circulates at nanomolar concentrations
in human plasma. Different posttranslationally modified HCC-1/CCL14a, including
Oglycosylated and Nterminally truncated variants of HCC-1/CCL14a, have been identified.
Whereas the 74 aa mature propeptide is a weak CCR1 agonist, the proteolytically processed
truncated HCC-1/CCL14a (aa 28 93) is a highly potent agonist of CCR1, CCR5 and to a lesser
extent, CCR3. HCC-1/CCL14a (aa 28 93) promotes chemotaxis of T lymphocytes, monocytes
and eosinophils, and inhibits infection of Mtropic human immunodeficiency virus type 1.
Activation of the HCC-1/CCL14a propeptide to active peptide is mediated by the urokinase
type plasminogen activator or plasmin.
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