描述：
CD40 is a type I transmembrane glycoprotein belonging to the TNF receptor superfamily.
The mature hCD40 consists of a 172 amino acid (aa) extracellular domain, a 22 aa
transmembrane region and a 62 aa cytoplasmic domain. Human and mouse CD40 share
62% aa identity. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated
monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor
cell lines. The extracellular domain has the cysteinerich repeat regions, which are
characteristic for many of the receptors of the TNF superfamily. Interaction of CD40 with its
ligand, CD40L, leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic
components to initiate signaling pathways. Early studies on the CD40-CD40L system revealed
its role in humoral immunity. Interaction between CD40L on T cells and CD40 on B cells
stimulated B cell proliferation and provided the signal for immunoglobulin isotype switching.
Mutations in the CD40L gene, which resulted in a CD40L molecule unable to interact with CD40,
are responsible for the hyper-IgM syndrome. Cross-linking of CD40 with antibodies or by CD40
binding to CD40L produces cell type-specific responses which include co-stimulation and
induction of proliferation, induction of cytokine production, rescue from apoptosis, and
upregulation of adhesion molecules. Some of the early events of intracellular signaling by the
CD40CD40L system include the association of the CD40 with TRAFs and the activation of
various kinases.
原厂资料：
CD40 is a type I transmembrane glycoprotein belonging to the TNF receptor superfamily.
The mature hCD40 consists of a 172 amino acid (aa) extracellular domain, a 22 aa
transmembrane region and a 62 aa cytoplasmic domain. Human and mouse CD40 share
62% aa identity. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated
monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor
cell lines. The extracellular domain has the cysteinerich repeat regions, which are
characteristic for many of the receptors of the TNF superfamily. Interaction of CD40 with its
ligand, CD40L, leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic
components to initiate signaling pathways. Early studies on the CD40-CD40L system revealed
its role in humoral immunity. Interaction between CD40L on T cells and CD40 on B cells
stimulated B cell proliferation and provided the signal for immunoglobulin isotype switching.
Mutations in the CD40L gene, which resulted in a CD40L molecule unable to interact with CD40,
are responsible for the hyper-IgM syndrome. Cross-linking of CD40 with antibodies or by CD40
binding to CD40L produces cell type-specific responses which include co-stimulation and
induction of proliferation, induction of cytokine production, rescue from apoptosis, and
upregulation of adhesion molecules. Some of the early events of intracellular signaling by the
CD40CD40L system include the association of the CD40 with TRAFs and the activation of
various kinases.
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