描述：
Activin RIB, also known as ALK-4, is a glycosylated 58 kDa type I transmembrane receptor
that belongs to the superfamily of TGF-β serine/threonine kinase receptors. Activin RIB
associates with Activin RIIB to form a receptor complex for activin and inhibin molecules.
These ligands bind to Activin RIIB which then associates with, and phosphorylates, the
cytoplasmic domain of Activin RIB to initiate signal transduction. Mature mouse Activin RIB
consists of a 103 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment,
and a 356 aa cytoplasmic region that includes the kinase domain. Within the ECD, mouse
Activin RIB shares 93% and 98% aa sequence identity with human and rat Activin RIB,
respectively. It shares 23%-38% aa sequence identity with other mouse typeI receptors
Activin RIA, BMPR-IA, BMPR-IB, and TGF-β RI. Activin receptor signaling is modulated by the
direct interaction of Activin RIB with cripto or inhibin binding protein. Activin RIB is excluded
from the signaling complex if Activin RIIB first binds inhibin and betaglycan.Activin RIB functions
in a wide variety of growth and differentiation processes, including embryonic cell fate and axis
determination, cell proliferation, apoptosis, and tumorigenesis.
原厂资料：
Activin RIB, also known as ALK-4, is a glycosylated 58 kDa type I transmembrane receptor
that belongs to the superfamily of TGF-β serine/threonine kinase receptors. Activin RIB
associates with Activin RIIB to form a receptor complex for activin and inhibin molecules.
These ligands bind to Activin RIIB which then associates with, and phosphorylates, the
cytoplasmic domain of Activin RIB to initiate signal transduction. Mature mouse Activin RIB
consists of a 103 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment,
and a 356 aa cytoplasmic region that includes the kinase domain. Within the ECD, mouse
Activin RIB shares 93% and 98% aa sequence identity with human and rat Activin RIB,
respectively. It shares 23%-38% aa sequence identity with other mouse typeI receptors
Activin RIA, BMPR-IA, BMPR-IB, and TGF-β RI. Activin receptor signaling is modulated by the
direct interaction of Activin RIB with cripto or inhibin binding protein. Activin RIB is excluded
from the signaling complex if Activin RIIB first binds inhibin and betaglycan.Activin RIB functions
in a wide variety of growth and differentiation processes, including embryonic cell fate and axis
determination, cell proliferation, apoptosis, and tumorigenesis.
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