Recombinant Rat FGF-BP Protein, CF (25 UG)

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at ambient temperature

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描述：

Fibroblast growth factor binding protein (FGF-BP), also known as HBp17, is a secreted

glycoprotein that increases the bioavailability of FGFs. Mature FGF-BP is a 34 kDa

Oglycosylated protein with five conserved intrachain disulfide bonds.FGF-BP contains

a heparinbinding domain (aa 113 -146) and a distinct FGFbinding region (aa 197 -238).

Mature rat FGF-BP shares 54% and 81% aa sequence identity with mouse and rat FGF-BP,

respectively. FGF-BP is expressed throughout development and in adult squamous epithelium.

It is upregulated in injured skin, renal tubular epithelium, and spinal nerves as well as in

carcinomas of the skin, colon, and pancreas. FGF-BP binds FGF -1, -2, -7, -10, and-22 which

are secreted and sequestered in the extracellular matrix (ECM). The interactions of FGF-BP

with heparin sulfate proteoglycans (HSPG) and FGF, modulates their activities. FGF-BP

enhances the mitogenic effects of FGFs, thereby contributing to epithelial, endothelial,

and neuronal tissue repair, angiogenesis, and tumor growth.

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