描述：
KC, a member of the alpha (CXC) chemokine subfamily, was initially identified as an
immediate early gene induced in mouse fibroblasts by platelet-derived growth factor.
KC cDNA encodes a 96 amino acid (aa) residue precursor protein with a predicted secretory
signal peptide that is removed to yield the mature protein. The protein sequence of mouse
KC shows approximately 63% identity to that of mouse MIP-2. KC is also approximately 60%
identical to the human GROs. It has been suggested that mouse KC and MIP-2 are the
orthologs of the human GROs and rat CINCs. In addition to mouse fibroblasts, KC is expressed
in macrophages and endothelial cells. Mouse KC is a potent neutrophil attractant and activator.
The functional receptor for KC has been identified as CXCR2. Based on the pattern of KC
expression in a number of inflammatory disease models, KC appears to have an important role
in inflammation. KC was found to be involved in monocyte arrest on atherosclerotic
endothelium and may also play a pathophysiological role in Alzheimer’s disease. Many
chemokines are substrates for selective proteolysis at the aminoterminus by various proteases
including dipeptidyl peptidase IV or matrix metalloproteases, resulting in truncated chemokine
isoforms with different (both enhanced or reduced) bioactivities. The naturally occurring 68
aa Nterminal truncated isoform of mouse KC is reported to be a more potent synergistic
growth stimulants for CFUGM. As a chemoattractant for hCXCR2 transfected mouse Baf/3
cells, the truncated form of mouse KC (aa 29 -96) is also approximately 5-fold more active
than 77 aa residue form of KC (aa 20 -96, R&D Systems, Catalog # 453-KC).
原厂资料：
KC, a member of the alpha (CXC) chemokine subfamily, was initially identified as an
immediate early gene induced in mouse fibroblasts by platelet-derived growth factor.
KC cDNA encodes a 96 amino acid (aa) residue precursor protein with a predicted secretory
signal peptide that is removed to yield the mature protein. The protein sequence of mouse
KC shows approximately 63% identity to that of mouse MIP-2. KC is also approximately 60%
identical to the human GROs. It has been suggested that mouse KC and MIP-2 are the
orthologs of the human GROs and rat CINCs. In addition to mouse fibroblasts, KC is expressed
in macrophages and endothelial cells. Mouse KC is a potent neutrophil attractant and activator.
The functional receptor for KC has been identified as CXCR2. Based on the pattern of KC
expression in a number of inflammatory disease models, KC appears to have an important role
in inflammation. KC was found to be involved in monocyte arrest on atherosclerotic
endothelium and may also play a pathophysiological role in Alzheimer’s disease. Many
chemokines are substrates for selective proteolysis at the aminoterminus by various proteases
including dipeptidyl peptidase IV or matrix metalloproteases, resulting in truncated chemokine
isoforms with different (both enhanced or reduced) bioactivities. The naturally occurring 68
aa Nterminal truncated isoform of mouse KC is reported to be a more potent synergistic
growth stimulants for CFUGM. As a chemoattractant for hCXCR2 transfected mouse Baf/3
cells, the truncated form of mouse KC (aa 29 -96) is also approximately 5-fold more active
than 77 aa residue form of KC (aa 20 -96, R&D Systems, Catalog # 453-KC).
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