描述：
FGF basic is a member of the FGF family, currently comprised of seven related mitogenic
proteins which show 35-55% amino acid conservation. FGF acidic and basic, unlike the
other members of the family, lack signal peptides and are apparently secreted by mechanisms
other than the classical protein secretion pathway. FGF basic has been isolated from a number
of sources, including neural tissue, pituitary, adrenal cortex, corpus luteum and placenta. This
factor contains four cysteine residues but reduced FGF basic retains full biological activity,
indicating that disulfide bonds are not required for this activity. Several reports indicate that a
variety of forms of FGF basic are produced as a result of Nterminal extensions. These
extensions apparently affect localization of FGF basic in cellular compartments but do not
affect biological activity. Studies indicate that binding of FGF to heparin or cell surface heparan
sulfate proteoglycans is necessary for binding of FGF to high affinity FGF receptors. FGF acidic
and basic appear to bind to the same high affinity receptors and show a similar range of
biological activities.FGF basic stimulates the proliferation of all cells of mesodermal origin,
and many cells of neuroectodermal, ectodermal and endodermal origin. The cells include
fibroblasts, endothelial cells, astrocytes, oligodendrocytes, neuroblasts, keratinocytes,
osteoblasts, smooth muscle cells, and melanocytes. FGF basic is chemotactic and mitogenic
for endothelial cells in vitro. FGF basic induces neuron differentiation, survival and
regeneration. FGF basic has also been shown to be crucial in modulating embryonic
development and differentiation. These observed in vitro functions of FGF basic suggest
FGF basic may play a role in vivo in the modulation of such normal processes as angiogenesis,
wound healing and tissue repair, embryonic development and differentiation, and neuronal
function and neural degeneration. Additionally, FGF basic may participate in the production
of a variety of pathological conditions resulting from excessive cell proliferation and excessive
angiogenesis.
原厂资料：
FGF basic is a member of the FGF family, currently comprised of seven related mitogenic
proteins which show 35-55% amino acid conservation. FGF acidic and basic, unlike the
other members of the family, lack signal peptides and are apparently secreted by mechanisms
other than the classical protein secretion pathway. FGF basic has been isolated from a number
of sources, including neural tissue, pituitary, adrenal cortex, corpus luteum and placenta. This
factor contains four cysteine residues but reduced FGF basic retains full biological activity,
indicating that disulfide bonds are not required for this activity. Several reports indicate that a
variety of forms of FGF basic are produced as a result of Nterminal extensions. These
extensions apparently affect localization of FGF basic in cellular compartments but do not
affect biological activity. Studies indicate that binding of FGF to heparin or cell surface heparan
sulfate proteoglycans is necessary for binding of FGF to high affinity FGF receptors. FGF acidic
and basic appear to bind to the same high affinity receptors and show a similar range of
biological activities.FGF basic stimulates the proliferation of all cells of mesodermal origin,
and many cells of neuroectodermal, ectodermal and endodermal origin. The cells include
fibroblasts, endothelial cells, astrocytes, oligodendrocytes, neuroblasts, keratinocytes,
osteoblasts, smooth muscle cells, and melanocytes. FGF basic is chemotactic and mitogenic
for endothelial cells in vitro. FGF basic induces neuron differentiation, survival and
regeneration. FGF basic has also been shown to be crucial in modulating embryonic
development and differentiation. These observed in vitro functions of FGF basic suggest
FGF basic may play a role in vivo in the modulation of such normal processes as angiogenesis,
wound healing and tissue repair, embryonic development and differentiation, and neuronal
function and neural degeneration. Additionally, FGF basic may participate in the production
of a variety of pathological conditions resulting from excessive cell proliferation and excessive
angiogenesis.
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