描述：
4-1BB ligand (4-1BBL) is a type II transmembrane glycoprotein belonging to the TNF
superfamily (TNFSF) and has been designated TNFSF9. Mouse 4-1BBL cDNA encodes a
309 amino acid residues (aa) protein with an 82 aa N-terminal cytoplasmic domain, a 21
aa transmembrane domain and a 206 aa C-terminal extracellular domain. The extracellular
domain of 4-1BBL has a tertiary structure similar to that of other TNFSF members, but shares
only low aa sequence homology (1416%). Murine 4-1BBL shares 36% aa sequence identity
with its human counterpart. 4-1BBL is predominantly expressed on activated antigen
presenting cells (APCs) such as B cells, macrophages and dendritic cells (DCs). It is also
expressed on most T and B lymphoma cell lines. A soluble 4-1BBL is released from the cell
surface following cellular activation via proteolytic cleavage by one or more sheddases. By
analogy to other TNFSF ligands, both the soluble and transmembrane 4-1BBL are expected
to exist as non-covalent homotrimers. 4-1BBL binds 4-1BB, a TNF receptor superfamily
member, TNFRSF9, which is also known as CD137 and ILA (induced by lymphocyte activation).
4-1BB is expressed on activated CD4+ and CD8+ T cells, thymocytes, and NK cells. It is also
expressed on monocytes, neutrophils, DCs and eosinophils. In response to 4-1BBL binding,
4-1BB transduces a T cell co-stimulatory signal in both CD4+ and CD8+ T cells to promote
survival and enhance proliferation, cytokine production and effector function. In dendritic
cells, 4-1BB is a DC-activating molecule that enhances cytokine production and upregulates
expression of B71 and B72 co-stimulatory molecules.
原厂资料：
4-1BB ligand (4-1BBL) is a type II transmembrane glycoprotein belonging to the TNF
superfamily (TNFSF) and has been designated TNFSF9. Mouse 4-1BBL cDNA encodes a
309 amino acid residues (aa) protein with an 82 aa N-terminal cytoplasmic domain, a 21
aa transmembrane domain and a 206 aa C-terminal extracellular domain. The extracellular
domain of 4-1BBL has a tertiary structure similar to that of other TNFSF members, but shares
only low aa sequence homology (1416%). Murine 4-1BBL shares 36% aa sequence identity
with its human counterpart. 4-1BBL is predominantly expressed on activated antigen
presenting cells (APCs) such as B cells, macrophages and dendritic cells (DCs). It is also
expressed on most T and B lymphoma cell lines. A soluble 4-1BBL is released from the cell
surface following cellular activation via proteolytic cleavage by one or more sheddases. By
analogy to other TNFSF ligands, both the soluble and transmembrane 4-1BBL are expected
to exist as non-covalent homotrimers. 4-1BBL binds 4-1BB, a TNF receptor superfamily
member, TNFRSF9, which is also known as CD137 and ILA (induced by lymphocyte activation).
4-1BB is expressed on activated CD4+ and CD8+ T cells, thymocytes, and NK cells. It is also
expressed on monocytes, neutrophils, DCs and eosinophils. In response to 4-1BBL binding,
4-1BB transduces a T cell co-stimulatory signal in both CD4+ and CD8+ T cells to promote
survival and enhance proliferation, cytokine production and effector function. In dendritic
cells, 4-1BB is a DC-activating molecule that enhances cytokine production and upregulates
expression of B71 and B72 co-stimulatory molecules.
京公网安备11010802025653 版权所有：北京逸优科技有限公司
