描述：
TNF-related weak inducer of apoptosis (TWEAK) is a type II transmembrane protein belonging
to the TNF superfamily and has been designated TNFSF12. Mouse TWEAK is a 249 amino acid
(aa) protein with an N-terminal 21 aa cytoplasmic domain, a 21 aa transmembrane region and
a 204 aa C-terminal extracellular domain.The primary structures of the extracellular domains of
human and mouse TWEAK are 88% identical. A soluble form of TWEAK is generated from the
membrane associated molecules by proteolytic cleavage suggesting that TWEAK may have
longrange effects. TWEAK is expressed widely in many tissues and cells. Although TWEAK has
been proposed as a ligand that signals through the death domain receptor 3 (DR3), a TNF
receptor superfamily member currently designated TNFRSF25, subsequent studies did not
demonstrate binding of TWEAK to cell lines that express DR3. In cells that lack DR3, TWEAK
has been shown to bind TWEAK receptor (TWEAK R), a novel TNF receptor superfamily member
designated TNFRSF12A. TWEAK R, also known as fibroblast growth factorinducible 14 (Fn14),
is a growth factorinducible immediateearly response gene that is expressed in fibroblasts,
hepatocellular carcinomas and endothelial cells. TWEAK-TWEAK R interaction has been shown
to promote NF-κB activation and mediate multiple cell death pathways. On endothelial cells,
TWEAK R plays a role in endothelial cell growth and migration. This effect of TWEAK is not due
to upregulation of VEGF.
原厂资料：
TNF-related weak inducer of apoptosis (TWEAK) is a type II transmembrane protein belonging
to the TNF superfamily and has been designated TNFSF12. Mouse TWEAK is a 249 amino acid
(aa) protein with an N-terminal 21 aa cytoplasmic domain, a 21 aa transmembrane region and
a 204 aa C-terminal extracellular domain.The primary structures of the extracellular domains of
human and mouse TWEAK are 88% identical. A soluble form of TWEAK is generated from the
membrane associated molecules by proteolytic cleavage suggesting that TWEAK may have
longrange effects. TWEAK is expressed widely in many tissues and cells. Although TWEAK has
been proposed as a ligand that signals through the death domain receptor 3 (DR3), a TNF
receptor superfamily member currently designated TNFRSF25, subsequent studies did not
demonstrate binding of TWEAK to cell lines that express DR3. In cells that lack DR3, TWEAK
has been shown to bind TWEAK receptor (TWEAK R), a novel TNF receptor superfamily member
designated TNFRSF12A. TWEAK R, also known as fibroblast growth factorinducible 14 (Fn14),
is a growth factorinducible immediateearly response gene that is expressed in fibroblasts,
hepatocellular carcinomas and endothelial cells. TWEAK-TWEAK R interaction has been shown
to promote NF-κB activation and mediate multiple cell death pathways. On endothelial cells,
TWEAK R plays a role in endothelial cell growth and migration. This effect of TWEAK is not due
to upregulation of VEGF.
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