描述：
OX40 Ligand (OX40L), also known as gp34, is a type II transmembrane glycoprotein
belonging to the TNF superfamily. Murine OX40L cDNA encodes a 198 amino acid
(aa) residue protein comprised of a 28 aa Nterminal cytoplasmic domain, a 20 aa
transmembrane segment, and a 150 aa C-terminal extracellular domain. Human
and murine OX40L share 46% sequence identity at the amino acid level. The OX40L
is expressed on activated antigen presenting cells such as B cells, macrophages, dendritic
cells, and on endothelial cells at the site of inflammation. The receptor for OX40L is OX40
(CD134) that is expressed predominantly on activated CD4+ T cells. Expression of OX40 is
transient following engagement of T cell receptors. Ligation of OX40L by OX40 stimulates
proliferation and differentiation of activated B cells, and increases immunoglobulin secretion.
The expression of OX40L on B cells is up-regulated by CD40 ligation. Engagement of the
OX40-OX40L system has costimulatory effects on T cells by stimulating the production
of cytokines by T helper cells and increasing the survival of memory T cells. Blocking of the
OX40-OX40L interaction in vitro inhibits costimulation resulting in decreased T cell
proliferation and adhesion of T cells to endothelial cells. Inhibition of the OX40-OX40L
interaction in disease models has beneficial effects in acute graftversushost disease,
inflammatory bowel disease and decreases the development of collageninduced arthritis
and experimental leishmaniasis.
原厂资料：
OX40 Ligand (OX40L), also known as gp34, is a type II transmembrane glycoprotein
belonging to the TNF superfamily. Murine OX40L cDNA encodes a 198 amino acid
(aa) residue protein comprised of a 28 aa Nterminal cytoplasmic domain, a 20 aa
transmembrane segment, and a 150 aa C-terminal extracellular domain. Human
and murine OX40L share 46% sequence identity at the amino acid level. The OX40L
is expressed on activated antigen presenting cells such as B cells, macrophages, dendritic
cells, and on endothelial cells at the site of inflammation. The receptor for OX40L is OX40
(CD134) that is expressed predominantly on activated CD4+ T cells. Expression of OX40 is
transient following engagement of T cell receptors. Ligation of OX40L by OX40 stimulates
proliferation and differentiation of activated B cells, and increases immunoglobulin secretion.
The expression of OX40L on B cells is up-regulated by CD40 ligation. Engagement of the
OX40-OX40L system has costimulatory effects on T cells by stimulating the production
of cytokines by T helper cells and increasing the survival of memory T cells. Blocking of the
OX40-OX40L interaction in vitro inhibits costimulation resulting in decreased T cell
proliferation and adhesion of T cells to endothelial cells. Inhibition of the OX40-OX40L
interaction in disease models has beneficial effects in acute graftversushost disease,
inflammatory bowel disease and decreases the development of collageninduced arthritis
and experimental leishmaniasis.
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