描述：
Endocrine glandderived vascular endothelial growth factor (EG-VEGF), also called
prokineticin 1 (PK1), is a member of the prokineticin family of secreted proteins
that share a common structural motif containing ten conserved cysteine residues
that form five pairs of disulfide bonds. Members of this family include the mammalian
EGVEGF/PK1 and PK2, as well as the venom protein A (VPRA) from the venom of black
mamba snake and the frog Bombina variegata, Bv8. Human EG-VEGF precursor is a 105
amino acid (aa) residue protein with a 19 aa signal peptide that is cleaved to yield a 86
aa mature protein. EG-VEGF is expressed inmultiple tissues including the gastrointestinal
(GI) tract and steroidogenic glands (testis, ovary, placenta and adrenal glands). EG-VEGF
has been shown to potently stimulate the contraction of GI smooth muscle. In addition,
EG-VEGF is a tissuespecific angiogenic factor that exhibits biological activities similar to
that of VEGF on select cells. It induces the proliferation, migration, and fenestration in
cultured endocrine glandderived capillary endothelial cells. EG-VEGF binds to and activates
two closely related G proteincoupled receptors, EG-VEGF/PK1R1 and EG-VEGF/PK2R2.
Activation of the receptors leads to stimulation of phosphoinositide turnover and activation
of p44/p42 MAP kinase signaling pathways.
原厂资料：
Endocrine glandderived vascular endothelial growth factor (EG-VEGF), also called
prokineticin 1 (PK1), is a member of the prokineticin family of secreted proteins
that share a common structural motif containing ten conserved cysteine residues
that form five pairs of disulfide bonds. Members of this family include the mammalian
EGVEGF/PK1 and PK2, as well as the venom protein A (VPRA) from the venom of black
mamba snake and the frog Bombina variegata, Bv8. Human EG-VEGF precursor is a 105
amino acid (aa) residue protein with a 19 aa signal peptide that is cleaved to yield a 86
aa mature protein. EG-VEGF is expressed inmultiple tissues including the gastrointestinal
(GI) tract and steroidogenic glands (testis, ovary, placenta and adrenal glands). EG-VEGF
has been shown to potently stimulate the contraction of GI smooth muscle. In addition,
EG-VEGF is a tissuespecific angiogenic factor that exhibits biological activities similar to
that of VEGF on select cells. It induces the proliferation, migration, and fenestration in
cultured endocrine glandderived capillary endothelial cells. EG-VEGF binds to and activates
two closely related G proteincoupled receptors, EG-VEGF/PK1R1 and EG-VEGF/PK2R2.
Activation of the receptors leads to stimulation of phosphoinositide turnover and activation
of p44/p42 MAP kinase signaling pathways.
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