描述：
Fibroblast Growth Factor 3 (FGF-3) belongs to the large FGF family which has at least
23 members. All FGF family members are heparinbinding growth factors with a core
120 amino acid (aa) FGF domain that allows for a common tertiary structure. FGFs are
expressed during embryonic development and in restricted adult tissues. They act on cells
of mesodermal and neuroectodermal origin to regulate diverse physiologic functions
including angiogenesis, cell growth, pattern formation, embryonic development, metabolic
regulation, cell migration, neurotrophic effects and tissue repair. Signaling receptors
for FGFs are type I transmembrane receptor tyrosine kinases belonging to the Ig superfamily.
Four distinct but related classes of FGF receptors, FGF R1, 2, 3, and 4, exist. Through
alternative splicing, multiple isoforms for FGF R1, 2 and 3, with distinct ligand recognition
profiles, are also generated.The FGF-3 gene, originally designated int2, was first identified
as a protooncogene activated in mouse mammary tumors by proviral integration.
Amplification of this gene has also been found frequently in human tumors. Human FGF-3
cDNA predicts a 239 aa precursor protein with a 17 aa signal peptide and a 222 aa secreted
mature protein with one potential Nlinked glycosylation site. Human and mouse FGF-3
share 88% aa sequence identity. The Xenopus and mammalian secreted FGF3 are processed
proteolytically at both the Nand Cterminus. FGF-3 binds with highaffinity to the IIIb
isoforms of FGF R1 and FGF R2. FGF3 also binds the IIIc isoform of FGF R2, but with lower
affinity . FGF-3 has been implicated in the induction of inner ear development. Studies
have suggested that FGF-3 and FGF-8 function synergistically in otic placode induction and
during neuronal development to regulate dorsoventral axis formation. During development,
the activities of FGF-3 and FGF-8 are regulated negatively by the sprouty family proteins
and by Sef (similar expression to f gf genes), a transmebrane protein that shares intracellular
sequence similarities with the IL-17 receptor.
原厂资料：
Fibroblast Growth Factor 3 (FGF-3) belongs to the large FGF family which has at least
23 members. All FGF family members are heparinbinding growth factors with a core
120 amino acid (aa) FGF domain that allows for a common tertiary structure. FGFs are
expressed during embryonic development and in restricted adult tissues. They act on cells
of mesodermal and neuroectodermal origin to regulate diverse physiologic functions
including angiogenesis, cell growth, pattern formation, embryonic development, metabolic
regulation, cell migration, neurotrophic effects and tissue repair. Signaling receptors
for FGFs are type I transmembrane receptor tyrosine kinases belonging to the Ig superfamily.
Four distinct but related classes of FGF receptors, FGF R1, 2, 3, and 4, exist. Through
alternative splicing, multiple isoforms for FGF R1, 2 and 3, with distinct ligand recognition
profiles, are also generated.The FGF-3 gene, originally designated int2, was first identified
as a protooncogene activated in mouse mammary tumors by proviral integration.
Amplification of this gene has also been found frequently in human tumors. Human FGF-3
cDNA predicts a 239 aa precursor protein with a 17 aa signal peptide and a 222 aa secreted
mature protein with one potential Nlinked glycosylation site. Human and mouse FGF-3
share 88% aa sequence identity. The Xenopus and mammalian secreted FGF3 are processed
proteolytically at both the Nand Cterminus. FGF-3 binds with highaffinity to the IIIb
isoforms of FGF R1 and FGF R2. FGF3 also binds the IIIc isoform of FGF R2, but with lower
affinity . FGF-3 has been implicated in the induction of inner ear development. Studies
have suggested that FGF-3 and FGF-8 function synergistically in otic placode induction and
during neuronal development to regulate dorsoventral axis formation. During development,
the activities of FGF-3 and FGF-8 are regulated negatively by the sprouty family proteins
and by Sef (similar expression to f gf genes), a transmebrane protein that shares intracellular
sequence similarities with the IL-17 receptor.
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