Recombinant Human IL-20 R alpha Fc Chimera Protein, CF (50 UG)

产品编号：RD-1176-IR-050 品牌：R&D 原厂货号：1176-IR-050
产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 细胞因子和生长因子 > 其它白细胞介素
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原厂资料：

Protein Construct:

Human IL-20 R alpha (Val30 - Lys250) Accession # Q9UHF4	DIEGRMD	Human IgG₁ (Pro100 - Lys330)
N-terminus		C-terminus

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

Reconstitution:
Reconstitute at 100 µg/mL in sterile PBS.

Shipping:
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage:
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
3 months, -20 to -70 °C under sterile conditions after reconstitution.

注意事项：

Molecule Information: IL-20 R alpha

Long Name: Interleukin 20 Receptor alpha

Aliases: CRF2-8; IL20RA; zcytor7

Entrez Gene IDs: 53832 (Human); 237310 (Mouse)

Background: IL-20 R alpha

View IL-20 R alpha IHC images.

IL-20 receptor alpha (IL-20 R alpha), also named IL-20 R1, CRF2-8, and ZCYTOR7, belongs to the class II cytokine receptor family, which includes 12 members. These receptors are characterized by the patterns of conserved amino acid residues (aa) in their extracellular domains, which are composed of tandem fibronectin type III domains. Class II cytokine receptors form heterodimeric signaling receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions. The gene for human IL-20 R alpha is mapped to chromosome 6 and encodes a 553 aa glycoprotein with a 29 aa signal peptide, a 221 aa extracellular domain, a 24 aa transmembrane region and a 279 aa intracellular domain.

IL-20 R alpha is widely expressed and is detected at high levels in multiple tissues including skin, testis, heart, placenta, salivary gland and prostate gland. The expression of IL-20 R alpha, together with that of IL-20 R beta, is upregulated in psoriatic skin lesions on keratinocytes, immune cells, and endothelial cells. IL-20 R alpha heterodimerizes with IL-20 R beta to form the functional receptor that mediates IL-19, IL-20 and IL-24 signals. IL-20 R alpha also heterodimerizes with IL-10 R beta to form the functional receptor complex for IL-26. Binding of these IL-10 family class II cytokines to their functional receptors induces activation of the JAK-STAT signal transduction pathway. At low ligand concentrations, STAT3 has been shown to be the predominant STAT proteins activated through either complexes.