描述：
B-cell activating factor (BAFF), also known as BlyS, TALL-1, TNAK, and zTNF4, is a TNF
ligand superfamily member and has been designated TNFSF13B. Produced by macrophages,
dendritic cells, and T lymphocytes, BAFF promotes the survival of B cells and is essential for
B cell maturation. BAFF binds to three TNF receptor superfamily members: Bcell maturation
antigen (BCMA/TNFRSF17), transmembrane activator and calciummodulator and cyclophilin
ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C).These
receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and
BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferationinducing ligand),
BAFF R selectively binds BAFF. The BAFF R extracellular domain lacks the TNF receptor
canonical cysteinerich domain (CRD) and contains only a partial CRD with four cysteine
residues. Human and mouse BAFF R share 56% aa sequence identity. BAFF R is highly
expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in
activated B cell, in resting CD4+T cells, in thymus and peripheral blood leukocytes. BAFF
knockout mice lack mature B cells. Similarly, A/WySnJ mice that are defective in BAFF R
intracellular signaling also lack mature B cells, suggesting that BAFF R is the critical receptor
for BAFF during B lymphopoiesis. In contrast, BCMAor TACIdeficient mice have no major
defect in Bcell development. While the function of BCMA is not defined, TACI has been
shown to control Bcell homeostasis and T cell independent immune responses.
原厂资料：
B-cell activating factor (BAFF), also known as BlyS, TALL-1, TNAK, and zTNF4, is a TNF
ligand superfamily member and has been designated TNFSF13B. Produced by macrophages,
dendritic cells, and T lymphocytes, BAFF promotes the survival of B cells and is essential for
B cell maturation. BAFF binds to three TNF receptor superfamily members: Bcell maturation
antigen (BCMA/TNFRSF17), transmembrane activator and calciummodulator and cyclophilin
ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C).These
receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and
BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferationinducing ligand),
BAFF R selectively binds BAFF. The BAFF R extracellular domain lacks the TNF receptor
canonical cysteinerich domain (CRD) and contains only a partial CRD with four cysteine
residues. Human and mouse BAFF R share 56% aa sequence identity. BAFF R is highly
expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in
activated B cell, in resting CD4+T cells, in thymus and peripheral blood leukocytes. BAFF
knockout mice lack mature B cells. Similarly, A/WySnJ mice that are defective in BAFF R
intracellular signaling also lack mature B cells, suggesting that BAFF R is the critical receptor
for BAFF during B lymphopoiesis. In contrast, BCMAor TACIdeficient mice have no major
defect in Bcell development. While the function of BCMA is not defined, TACI has been
shown to control Bcell homeostasis and T cell independent immune responses.
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