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描述:
CXCL7 is a member of the alpha (CXC) subfamily of chemokines. Mouse CXCL7
cDNA encodes a 113 amino acid residue precursor protein that shares 72% amino
acid sequence identity with rat CXCL7 (accession number AAK30166). The recombinant
mouse CXCL7 produced by R&D Systems has been shown to chemoattract human
CXCR2 transfected mouse BaF/3 cells, but not human CXCR1 transfected mouse
BaF3 cells. Two isoforms of mouse CXCL7 have been produced at R&D Systems.
The Ile48 Ile109 mouse CXCL7 isoform (R&D Systems, Catalog # 1091CK) has been
shown to be 200fold more potent than the Lys40 Tyr113 isoform (R&D Systems,
Catalog # 763CK) as a chemoattractant for mouse BaF/3 cells transfected with
human CXCR2.
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