描述：
BMP8, also known as osteogenic protein 2 (OP2), was first isolated from a hippocampal
library in a screen to identify relatives of BMP7/OP1. BMPs are a family of structurally
and functionally related proteins and represent a subfamily of the transforming growth
factor β (TGFβ) superfamily. BMPs are involved in a wide range of processes including
embryogenesis, tissue morphogenesis, cell differentiation and migration, and tumorigenesis.
Cellular responses to BMPs are mediated by hetero-oligomeric complexes of type I and
type II serine/threonine kinase receptors. BMP-8a and BMP8b, produced from separate
genes, share 98% aa sequence identity in human but only 74% in mouse within the mature
regions. Human BMP-8a is synthesized as a 402 aa precursor protein that is cleaved
between Arg263 and Ala264 to release the Cterminal mature protein. Mature human
BMP-8a shares 90% and 68% aa sequence identity with mouse mature BMP-8a and 8b,
respectively. BMP-8a is expressed during pregnancy in the deciduum and trophoblast cells,
by inner root sheath cells of developing hair follicles, and by the epididymis and spermatids.
In the mouse it cooperates with BMP7 in the maintenance of spermatogenesis but is not
required for the initiation of spermatogenesis. BMP-8b, in contrast, is required for both
the initiation and maintenance of spermatogenesis. BMP-8a is induced during osteoblast
differentiation at the onset of mineralization and during the osteogenic phase of bone
repair in osteoblasts and osteocytes. BMP-8a/b is also highly expressed in osteosarcomas.
原厂资料：
BMP8, also known as osteogenic protein 2 (OP2), was first isolated from a hippocampal
library in a screen to identify relatives of BMP7/OP1. BMPs are a family of structurally
and functionally related proteins and represent a subfamily of the transforming growth
factor β (TGFβ) superfamily. BMPs are involved in a wide range of processes including
embryogenesis, tissue morphogenesis, cell differentiation and migration, and tumorigenesis.
Cellular responses to BMPs are mediated by hetero-oligomeric complexes of type I and
type II serine/threonine kinase receptors. BMP-8a and BMP8b, produced from separate
genes, share 98% aa sequence identity in human but only 74% in mouse within the mature
regions. Human BMP-8a is synthesized as a 402 aa precursor protein that is cleaved
between Arg263 and Ala264 to release the Cterminal mature protein. Mature human
BMP-8a shares 90% and 68% aa sequence identity with mouse mature BMP-8a and 8b,
respectively. BMP-8a is expressed during pregnancy in the deciduum and trophoblast cells,
by inner root sheath cells of developing hair follicles, and by the epididymis and spermatids.
In the mouse it cooperates with BMP7 in the maintenance of spermatogenesis but is not
required for the initiation of spermatogenesis. BMP-8b, in contrast, is required for both
the initiation and maintenance of spermatogenesis. BMP-8a is induced during osteoblast
differentiation at the onset of mineralization and during the osteogenic phase of bone
repair in osteoblasts and osteocytes. BMP-8a/b is also highly expressed in osteosarcomas.
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