描述：
BMP8, also known as osteogenic protein 2 (OP2), was first isolated from
a hippocampal library in a screen to identify relatives of BMP7 (OP1). BMPs
are a family of structurally and functionally related proteins and represent a
subfamily of the transforming growth factor β (TGFβ) superfamily. BMPs
were originally identified as protein regulators of cartilage and bone formation.
They have since been shown to be involved in embryogenesis and morphogenesis
of various tissues and organs. BMPs play roles in regulating growth, differentiation,
chemotaxis, and apoptosis of various cell types, including mesenchymal, epithelial,
hematopoetic, and neuronal cells. There exist two highly related and closely linked
genes, designated BMP8a and 8b in mice and humans. For humans, the protein
products of these two genes share 98% amino acid (aa) sequence identity in their
pro-and mature regions. However in the mouse, the two proteins share 89% and
76% aa sequence homology in their proand mature regions, respectively. Mature
human BMP8a shares 91% and 70% aa sequence identity with mouse BMP8a
and 8b, respectively. Human BMP8a is synthesized as a large precursor protein
that is cleaved at a dibasic cleavage site (RTPR) between aa residues 263 and 264
to release a 139 aa carboxyterminal domain. Expression patterns of the BMP8
genes indicate that they regulate aspects of cell proliferation and/or differentiation
during spermatogenesis and formation of the placenta. BMP8 is also highly
expressed in osteosarcomas.
原厂资料：
BMP8, also known as osteogenic protein 2 (OP2), was first isolated from
a hippocampal library in a screen to identify relatives of BMP7 (OP1). BMPs
are a family of structurally and functionally related proteins and represent a
subfamily of the transforming growth factor β (TGFβ) superfamily. BMPs
were originally identified as protein regulators of cartilage and bone formation.
They have since been shown to be involved in embryogenesis and morphogenesis
of various tissues and organs. BMPs play roles in regulating growth, differentiation,
chemotaxis, and apoptosis of various cell types, including mesenchymal, epithelial,
hematopoetic, and neuronal cells. There exist two highly related and closely linked
genes, designated BMP8a and 8b in mice and humans. For humans, the protein
products of these two genes share 98% amino acid (aa) sequence identity in their
pro-and mature regions. However in the mouse, the two proteins share 89% and
76% aa sequence homology in their proand mature regions, respectively. Mature
human BMP8a shares 91% and 70% aa sequence identity with mouse BMP8a
and 8b, respectively. Human BMP8a is synthesized as a large precursor protein
that is cleaved at a dibasic cleavage site (RTPR) between aa residues 263 and 264
to release a 139 aa carboxyterminal domain. Expression patterns of the BMP8
genes indicate that they regulate aspects of cell proliferation and/or differentiation
during spermatogenesis and formation of the placenta. BMP8 is also highly
expressed in osteosarcomas.
京公网安备11010802025653 版权所有：北京逸优科技有限公司
