描述：
OX40 Ligand (OX40L), also known as gp34, is a type II transmembrane glycoprotein
belonging to the TNF superfamily. Human OX40L cDNA encodes a 183 amino acids (aa)
polypeptide with an aminoterminal cytoplasmic domain (aa 123) and a carboxyterminal
extracellular domain (aa 51183). It shares 46% aa sequence identity with the mouse
counterpart.OX40L is expressed on the surface of activated B cells, T cells, dendritic cells
and endothelial cells.Similarly to other TNF superfamily members,
membranebound OX40 Ligand exists as a homotrimer.
OX40L binds to OX40 (CD134), a member of the TNF receptor superfamily that is
expressed predominantly on activated CD4+ T cells.
OX40 Ligand is one of the costimulatory molecules in the immune system
that includes B7, CD40 Ligand, CD30 Ligand, CD27 Ligand and 41BB Ligand.
Because OX40 appears as a late activationinduced T cell surface antigen,
it has been speculated that the major function of OX40OX40L interaction
is to transmit a late costimulatory signal to promote the survival and
proliferation of activated CD4+ T cells and prolong the immune response.
Engagement of OX40 on activated T cells in situ in tumors has been shown to
augment immune responses and subsequent tumor regression.
原厂资料：
OX40 Ligand (OX40L), also known as gp34, is a type II transmembrane glycoprotein
belonging to the TNF superfamily. Human OX40L cDNA encodes a 183 amino acids (aa)
polypeptide with an aminoterminal cytoplasmic domain (aa 123) and a carboxyterminal
extracellular domain (aa 51183). It shares 46% aa sequence identity with the mouse
counterpart.OX40L is expressed on the surface of activated B cells, T cells, dendritic cells
and endothelial cells.Similarly to other TNF superfamily members,
membranebound OX40 Ligand exists as a homotrimer.
OX40L binds to OX40 (CD134), a member of the TNF receptor superfamily that is
expressed predominantly on activated CD4+ T cells.
OX40 Ligand is one of the costimulatory molecules in the immune system
that includes B7, CD40 Ligand, CD30 Ligand, CD27 Ligand and 41BB Ligand.
Because OX40 appears as a late activationinduced T cell surface antigen,
it has been speculated that the major function of OX40OX40L interaction
is to transmit a late costimulatory signal to promote the survival and
proliferation of activated CD4+ T cells and prolong the immune response.
Engagement of OX40 on activated T cells in situ in tumors has been shown to
augment immune responses and subsequent tumor regression.
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