PDGF isoforms exert their cellular effects by binding to the structurally similar receptor tyrosine kinases (RTK), PDGF R alpha (CD140a) and PDGF R beta (CD140b). PDGF-AA, PDGF-BB, PDGF-CC, PDGF-DD and PDGF-AB isofoms bind the two distinct cell surface PDGF receptors with different affinities. Both PDGF R alpha and PDGF R beta are members of the class III subfamily of RTK which are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo- and heterodimerization leading to signal transduction. The expression of PDGF alpha and beta receptors is independently regulated in various cell types.
原厂资料：
Protein Construct:
Mouse PDGF R beta
(Leu32 - Lys530)
Accession # P05622
IEGRMD
Human IgG1
(Pro100 - Lys330)
N-terminus
C-terminus
What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
Reconstitution:
Reconstitute at 100 µg/mL in sterile PBS.
Shipping:
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
3 months, -20 to -70 °C under sterile conditions after reconstitution.
京公网安备11010802025653 版权所有：北京逸优科技有限公司
