描述：
Human IL2 receptor alpha (IL2 Rα), also known as Tac antigen and CD25,
was initially identified as a 55 kDa membrane glycoprotein that is capable of binding IL2.
The IL2 Rα cDNA encodes a 272 amino acid residue precursor type I
membrane protein with a 21 residue signal peptide,
a 219 residue extracellular region, a 19 residue transmmbrane
region and a 13 residue cytoplasmic domain.
IL2 Rα lacks structural features characteristic of members of the cytokine receptor
superfamily. By itself, IL2 Rα binds IL2 with low affinity. However,
when IL2 Rα is associated with the IL2 receptor beta and gamma chains,
a high affinity heterotrimeric receptor complex that transduces IL2 signals is formed.
Soluble forms of many cytokine receptors have been reported,
and a soluble form of IL2 Rα (IL2 sRα) appears in serum,
concomitant with its increased expression on cells.
The function of the soluble IL2 Rα is unclear. Increased levels of IL2 sRα
in biological fluids reportedly correlate with increased T and B cell activation and
immune system activation.
Increased serum concentration of IL2 sRα has been observed
in patients with a variety of inflammatory conditions and in the course of
some leukemias and lymphomas.
原厂资料：
Human IL2 receptor alpha (IL2 Rα), also known as Tac antigen and CD25,
was initially identified as a 55 kDa membrane glycoprotein that is capable of binding IL2.
The IL2 Rα cDNA encodes a 272 amino acid residue precursor type I
membrane protein with a 21 residue signal peptide,
a 219 residue extracellular region, a 19 residue transmmbrane
region and a 13 residue cytoplasmic domain.
IL2 Rα lacks structural features characteristic of members of the cytokine receptor
superfamily. By itself, IL2 Rα binds IL2 with low affinity. However,
when IL2 Rα is associated with the IL2 receptor beta and gamma chains,
a high affinity heterotrimeric receptor complex that transduces IL2 signals is formed.
Soluble forms of many cytokine receptors have been reported,
and a soluble form of IL2 Rα (IL2 sRα) appears in serum,
concomitant with its increased expression on cells.
The function of the soluble IL2 Rα is unclear. Increased levels of IL2 sRα
in biological fluids reportedly correlate with increased T and B cell activation and
immune system activation.
Increased serum concentration of IL2 sRα has been observed
in patients with a variety of inflammatory conditions and in the course of
some leukemias and lymphomas.
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