Interleukin 2 was initially identified as a T cell growth factor that is produced by T cells following activation by mitogens or antigens.
Since then, it has been shown thatin addition to its T cell growth factor activity, IL2 can also stimulate the growth and differentiation of B cells, natural killer (NK) cells, lymphocyte activated killer (LAK) cells, monocytes/macrophages and oligodendrocytes.
At the amino acid sequence level, there is approximately 72% similarity between mature porcine and human IL2.
The biological activity of IL2 is mediated by the binding of IL2 to cell surface receptor complexes.The functional highaffinity receptor of IL2 is composed of three distinct polypeptide chains, the IL2 receptor α, β and γ subunits. The intermediateaffinity IL2 receptor complex, which lacks the αsubunit, but contains both the β and γ subunits, is also capable of transducing the IL2 signal.
In T cells, the β and γ subunits are shared with the IL15 receptor complex.
The γ chain of the IL2 receptor complex has also been shown to be a subunit of the receptor complexes of IL4, IL7, and IL9.
原厂资料：
Interleukin 2 was initially identified as a T cell growth factor that is produced by T cells following activation by mitogens or antigens.
Since then, it has been shown thatin addition to its T cell growth factor activity, IL2 can also stimulate the growth and differentiation of B cells, natural killer (NK) cells, lymphocyte activated killer (LAK) cells, monocytes/macrophages and oligodendrocytes.
At the amino acid sequence level, there is approximately 72% similarity between mature porcine and human IL2.
The biological activity of IL2 is mediated by the binding of IL2 to cell surface receptor complexes.The functional highaffinity receptor of IL2 is composed of three distinct polypeptide chains, the IL2 receptor α, β and γ subunits. The intermediateaffinity IL2 receptor complex, which lacks the αsubunit, but contains both the β and γ subunits, is also capable of transducing the IL2 signal.
In T cells, the β and γ subunits are shared with the IL15 receptor complex.
The γ chain of the IL2 receptor complex has also been shown to be a subunit of the receptor complexes of IL4, IL7, and IL9.
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