IL1 is a name that designates two pleiotropic cytokines,
IL1α (IL1F1) and IL1β (IL1F2), which are the products of distinct genes.
IL1α and IL1β are structurally related polypeptides that share approximately 27% amino acid (aa) identity in cotton rat.
Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins.
While IL1α and IL1β are regulated independently, they bind to the same receptor and exert identical biological effects.
IL1 RI binds directly to IL1α or IL1β and then associates with IL1 R accessory protein (IL1 R3/IL1 R AcP) to form a highaffinity receptor complex that is competent for signal transduction.
IL1 RII has high affinity for IL1β but functions as a decoy receptor and negative regulator of IL1β activity.
IL1rafunctions as a competitive antagonist by preventing IL1α and IL1β from interacting with IL-1 RI (14). The cotton rat IL1β cDNA encodes a 267 aa precursor.
A 115 aa propeptide is cleaved intracellularly by the cysteine protease IL1βconverting enzyme (Caspase1/ICE) to generate the active cytokine (5, 6).
The 17 kDa mature cotton rat IL1β shares 90% aa sequence identity with mouse and rat and 65% 78% with canine, equine, feline, human, porcine, and rhesus IL1β.
原厂资料：
IL1 is a name that designates two pleiotropic cytokines,
IL1α (IL1F1) and IL1β (IL1F2), which are the products of distinct genes.
IL1α and IL1β are structurally related polypeptides that share approximately 27% amino acid (aa) identity in cotton rat.
Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins.
While IL1α and IL1β are regulated independently, they bind to the same receptor and exert identical biological effects.
IL1 RI binds directly to IL1α or IL1β and then associates with IL1 R accessory protein (IL1 R3/IL1 R AcP) to form a highaffinity receptor complex that is competent for signal transduction.
IL1 RII has high affinity for IL1β but functions as a decoy receptor and negative regulator of IL1β activity.
IL1rafunctions as a competitive antagonist by preventing IL1α and IL1β from interacting with IL-1 RI (14). The cotton rat IL1β cDNA encodes a 267 aa precursor.
A 115 aa propeptide is cleaved intracellularly by the cysteine protease IL1βconverting enzyme (Caspase1/ICE) to generate the active cytokine (5, 6).
The 17 kDa mature cotton rat IL1β shares 90% aa sequence identity with mouse and rat and 65% 78% with canine, equine, feline, human, porcine, and rhesus IL1β.
京公网安备11010802025653 版权所有：北京逸优科技有限公司
