CHEK2 (CHK2) is a serine⁄threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in this gene has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins.
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Storage Buffer: 50mM Tris, pH 7.5, 150mM NaCl, 0.5mM EDTA, 0.04% Triton X-100, 4mM DTT, 50% glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.