Bone morphogenetic protein 3 (BMP-3), otherwise known as Osteogenin, is highly expressed in adult bone, especially chondroblasts, osteoblasts and osteoclasts, and, like other BMPs, induces bone and cartilage development. BMP-3 acts as an inhibitor of osteogenesis and bone formation, through the activation of a signalling cascade, which antagonizes pro-osteogenic BMP signalling. PHP246 corresponds to residues 361 to 472 of the 472 amino acid BMP-3 precursor protein.
Target Species
Human
Product Form
Purified recombinant protein - lyophilised
Preparation
Purified recombinant BMP-3 expressed in E.coli
Preservative Stabilisers
None present
Reconstitution
Reconstitute with 500ul distilled water
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. AbD Serotec recommend that the vial is gently mixed after reconstitution.
Purity
>95% by SDS PAGE and HPLC analysis
Activity
Determined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells.
京公网安备11010802025653 版权所有：北京逸优科技有限公司
