GM-CSF (granulocyte-macrophage colony-stimulating factor) is a haematopoietic growth factor which exists in both glycosylated and non-glycosylated biologically active forms, and stimulates the development of granulocytes, macrophages, early megakaryocytes and eosinophil progenitor cells. The ability of recombinant GM-CSF to increase haematopoietic cell recovery has become a focus area in the therapeutic treatment of patients following bone marrow transplantation.
Target Species
Human
Product Form
Purified recombinant protein - lyophilised
Preparation
Purified recombinant GM-CSF expressed in E. coli
Preservative Stabilisers
None present
Molecular Weight
14.6kD (128 amino acid residues)
Reconstitution
Reconstitute with 200ul distilled water
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. AbD Serotec recommend that the vial is gently mixed after reconstitution.
Purity
>98% by SDS PAGE/HPLC analysis
Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is = 0.1 ng/ml, corresponding to a specific activity of = 1 x 107 units/mg.
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