FGF 4 (fibroblast growth factor 4) is a member of the heparin-binding growth factors family which act as promoters of cellular differentiation and proliferation, and therefore play key roles in embryonic development, morphogenesis, tissue regeneration and tumour growth and invasion. Studies have shown that FGF 4 signals through binding to the FGF Receptors (FGFRs) 1c, 2c, 3c, and 4.
Target Species
Human
Product Form
Purified recombinant protein - lyophilised
Preparation
Purified recombinant FGF 4 expressed in E.coli
Preservative Stabilisers
None present
Molecular Weight
19.7kD (182 amino acid residues)
Reconstitution
Reconstitute with 250ul distilled water
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. AbD Serotec recommend that the vial is gently mixed after reconstitution.
Purity
>95% by SDS PAGE and HPLC analysis
Activity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is = 0.5 ng/ml, corresponding to a specific activity of = 2 x 106 units/mg.
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