Abl Protein Tyrosine Kinase (Abl)

• 产品编号：P6050L      品牌：New England Biolabs       原厂货号：P6050L
• 产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 蛋白激酶 > 胞质酪氨酸激酶
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描述：

Abl Protein Tyrosine Kinase (AbI) is a truncated form of the v-AbI Protein Tyrosine Kinase, a partner in the Gag-Abl fusion protein of the Abelson murine leukemia virus. Abl contains 407 amino acids (residues 237-643 of the p120-gag-abl polyprotein), which include the kinase catalytic domain, SH2 domain on the N-terminus and the I237M mutation. This truncated form of v-Abl is identical to the normal c-Abl (1-3). Abl is autophosphorylated on tyrosine(s)(2). 

Highlights

• Protein tyrosine kinase
• Abelson Murine Leukemia Virus, recombinant (E. coli)

Product Source

Isolated from a strain of E. coli that carries the truncated AbI Protein Kinase encoded by the Abelson murine leukemia virus under the control of a T7 expression system (kindly provided by Dr. S. Goff).

Recognition Determinant

The recognition motif for phosphorylation by Abl is I/V/LYXXP/F. Abl, like many cytosolic protein tyrosine kinases, preferentially phosphorylates sites recognized by its own SH2 domain, selects substrates with large hydrophobic amino acids at the +3 position and β-branched amino acids at the -1 position (4).

原厂资料：