Highest biotin-binding streptavidin magnetic beads on the market NanoLink™ Streptavidin Magnetic Beadshave the highest biotin-binding capacity on the market. Higher binding translates into reduced bead mass required to immobilize a biotinylated sample and lower background noise from nonspecific binding, resulting in better signals and lower net costs.
NanoLink™ Outperforms Competitors on Free-Biotin Binding Capacity
The secret is in the crosslinking NanoLink™ Streptavidin Magnetic Beads are 0.8 micron-sized, super-paramagnetic, hydrophobic, and polymer–encapsulated (no exposed iron), with a fast (<2 min) magnetic response time. They are stable in colloidal form and in detergents. The key to high biotin binding is in the unique covalently crosslinked streptavidin, based on Solulink’s proprietary linking technology. The high surface area, when combined with our efficient linking chemistry, produces a consistent, ultra-high, biotin-binding bead. The high surface area and lower nonspecific binding makes NanoLink™ Steptavidin Magnetic Beads ideal for immobilizations and Co-IP applications.
NanoLink™ Binding Capacity vs. Competition
Ligand
NanoLink (0.8 μm) Binding
Competitor's 1 μm Bead Binding
Free biotin
>14 nmol/mg
>1,300 pmol/mg
Biotinylated oligo (23-mer)
>2.5 nmol/mg
NA
Biotinylated IgG (3 biotins per IgG)
>1.7 nmol/mg
(250 μg/mg)
0.12 nmol/mg
(20 μg/mg)
Advantages
Highest Biotin Binding – Supported by unique streptavidin crosslinking
Fast (<2 min) Response Time – Saves time and accommodates viscous samples
Versatile – NanoLink™ beads areideal for immobilizations and Co-IP applications
Applications
Capture, immobilization, and separation of biotin-labeled biomolecules such as genomic DNA, RNA, PCR products, oligonucleotides, peptides, or antibodies. We recommend biotinylation with the ChromaLink™ Biotin Labeling Kit (Cat. No. B-9007-105K).
High-throughput robotic applications where high biotin-binding loads must be removed or immobilized without the presence of an iron leachate.
NanoLink™ Streptavidin Magnetic Beads are ideally suited for generating single-stranded PCR templates that can dramatically increase hybridization efficiency to complementary probes by removal of the unbiotinylated, competing PCR strand.
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