The pGL4.71[hRlucP] Vector encodes the luciferase reporter genehRlucP(Renilla reniformis) and is designed for high expression and reduced anomalous transcription. The pGL4 Vectors are engineered with fewer consensus regulatory sequences and a synthetic gene, which has been codon optimized for mammalian expression. The pGL4.71[hRlucP] Vector has no promoter. However, it contains a multiple cloning region that allows for cloning of a promoter of choice. ThehRlucPluciferase reporter gene contains hPEST, a protein destabilization sequence. The protein encoded byhRlucPresponds more quickly and with greater magnitude to changes in transcriptional activity than thehRlucgene, its more stable counterpart.