CD19 is a 95kD glycoprotein, expressed by all human B lymphocytes. It is expressed on precursor B cells prior to the expression of cytoplasmic m chain. CD19 expression is lost during differentiation to plasma cells.
CD5 is a 67kD glycoprotein expressed by all mature T cells and by a subset of mature B cells. CD5 has been shown to act as a ligand for the B cell marker CD72. CD5 positive B cells have been implicated in the pathogenesis of various autoimmune disorders and are the normal counterpart of the malignant cells in B cell chronic lymphocytic leukaemia.
This combination of antibodies is useful for simultaneously enumerating CD5 and CD19 positive cells. It may find particular application in the study of CD5 positive B lymphocytes and in the study of chronic lymphoproliferative diseases.
Application
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.
Application Name
Yes
No
Not Determined
Suggested Dilution
Flow Cytometry
Neat
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10ul to label 100ul of whole blood.
Storage
Prior to reconstitution store at +4oC. Following reconstitution store at +4oC.
DO NOT FREEZE.
This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
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