ON-TARGETplus阴性对照产品(ON-TARGETplus Negative Control Reagents) 产品特点:
特殊设计和化学修饰技术确保不靶向任何已知的人、小鼠和大鼠基因;
基因芯片检测证实不对任何人源基因产生沉默效果。
产品应用:
可作为人人、小鼠和大鼠基因单条siRNAs或者SMARTpool® 试剂是否特异性的对照产品;
可将序列特异性沉默和非特异性沉默有效区分。
原厂资料:
Thermo Scientific ON-TARGETplus Non-targeting Control Pool is the ideal negative control for RNAi experiments in human, mouse, and rat cells. The four component ON-TARGETplus Non-targeting siRNAs were designed to leverage seed-region optimization and patented ON-TARGETplus modification patterns to have fewer off-targets than traditionally designed negative control siRNAs, and screened by genomewide microarray analysis. Changes in mRNA or protein levels in cells treated with these controls reflect a baseline cellular response that can be compared to the levels in cells treated with target-specific siRNA.
Highlights
• Ideal negative control for RNAi experiments in human, mouse, and rat cells
• Chemically matched for use with ON-TARGETplus siRNA reagents
• Screened by genome-wide microarray analysis for minimal off-targets