siSTABLE® 阳性对照试剂 (siSTABLE® Positive Control Reagents)
产品特点：
特殊化学修饰增强siRNA在富含核酸酶环境下的稳定性（见下图）。
实验验证的可高效沉默人和小鼠细胞中的高表达基因。
产品应用：
通过检测靶基因的沉默效果量化siRNA在人、小鼠和大鼠细胞的转染效率。
可用于siSTABLE产品siRNA沉默的对照产品。
Figure. siSTABLE siRNA and an alternative commercially available modified siRNA targeting human cyclophilin B were incubated in 100% human serum for 5 days. The integrity of the siRNAs was analyzed by non-denaturing polyacrylamide gel electrophoresis. (*alternative commercially available modified siRNA)
原厂资料：
Thermo Scientific siSTABLE GAPD Control siRNA is a validated positive control, guaranteed to silence GAPD in mouse cells. This control siRNA is chemically modified to significantly extend siRNA stability and is recommended for use as a positive control in experiments using siSTABLE modified siRNA against a target gene or where increased stability of the control is desired.
Also known as glyceraldehyde-3-phosphate dehydrogenase or GAPDH, GAPD is an important enzyme in carbohydrate metabolism that is well conserved across the animal kingdom. This gene is abundantly expressed in most cells, and because it is non-essential, knockdown of the corresponding mRNA does not affect cell viability. Targets accession number NM_001001303.
Highlights
• Experimentally validated for consistent, potent silencing of cyclophilin B in human cells
• Chemically modified to significantly extend siRNA stability
• Suitable for use in experimental settings with high nuclease activity, including in vivo studies
To request a larger quantity or in vivo processing of this control product, please email Technical Support, or call 1-800-235-9880. International customers, please call 303-604-9499 or your local Sales Representative.
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