siSTABLE® 阳性对照试剂 (siSTABLE® Positive Control Reagents)
产品特点：
特殊化学修饰增强siRNA在富含核酸酶环境下的稳定性（见下图）。
实验验证的可高效沉默人和小鼠细胞中的高表达基因。
产品应用：
通过检测靶基因的沉默效果量化siRNA在人、小鼠和大鼠细胞的转染效率。
可用于siSTABLE产品siRNA沉默的对照产品。
Figure. siSTABLE siRNA and an alternative commercially available modified siRNA targeting human cyclophilin B were incubated in 100% human serum for 5 days. The integrity of the siRNAs was analyzed by non-denaturing polyacrylamide gel electrophoresis. (*alternative commercially available modified siRNA)
原厂资料：
Thermo Scientific siSTABLE Cyclophilin B Control siRNA is a validated positive control, guaranteed to silence cyclophilin B in mouse cells. This control siRNA is chemically modified to significantly extend siRNA stability and is recommended for use as a positive control in experiments using siSTABLE-modified siRNA against a target gene or where increased stability of the siRNA is desired.
Also known as peptidylprolyl isomerase B (PPIB), cyclophilin B is associated with the secretory pathway. This gene is abundantly expressed in most cells, and because it is non-essential, knockdown of the corresponding mRNA does not affect cell viability. Targets accession number NM_011149.
Highlights
• Experimentally validated for consistent, potent silencing of cyclophilin B in mouse cells
• Chemically modified to significantly extend siRNA stability
• Suitable for use in experimental settings with high nuclease activity, including in vivo studies
To request a larger quantity or in vivo processing of this control product, please email Technical Support, or call 1-800-235-9880. International customers, please call 303-604-9499 or your local Sales Representative.
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