Tyrosinase (T311) Mouse mAb (IHC Specific)

• 产品编号：CST-9319S      品牌：CST       原厂货号：9319S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Tyrosinase (T311) Mouse mAb鼠单抗用于检测内源性酪氨酸酶总蛋白水平。该单抗通过用纯化的重组酪氨酸酶蛋白免疫动物制备而得。酪氨酸酶位于黑色素小体的膜上(1)，是黑色素合成的关键酶(1,2)。该蛋白是黑色素细胞分化抗原，在黑色素细胞和黑色素瘤细胞表面表达(1,3)。酪氨酸酶被认为是黑色素癌疫苗的潜在抗原靶点(1)。

1. Chen, Y.T. et al. (1995) Proc Natl Acad Sci USA 92, 8125-9.
2. Kwon, B.S. (1993) J Invest Dermatol 100, 134S-140S.
3. Kwon, B.S. et al. (1987) Proc Natl Acad Sci USA 84, 7473-7.

原厂资料：

Specificity / Sensitivity

Tyrosinase (T311) Mouse mAb detects endogenous levels of total tyrosinase protein.

Source / Purification

Tyrosinase (T311) Mouse mAb is produced by immunizing animals with a purified recombinant tyrosinase.

Background

Tyrosinase, found in the membrane of melanosomes (1), is a key enzyme in the biosynthesis of melanin pigments (1,2). It is a melanocyte differentiation antigen and is expressed in normal melanocytes and malignant melanomas (1,3). Tyrosinase is implicated to be an antigen target for melanoma vaccines (1).

1. Chen, Y.T. et al. (1995) Proc Natl Acad Sci USA 92, 8125-9.
2. Kwon, B.S. (1993) J Invest Dermatol 100, 134S-140S.
3. Kwon, B.S. et al. (1987) Proc Natl Acad Sci USA 84, 7473-7.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.