RRM1 (D12F12) XP^? Rabbit mAb

• 产品编号：CST-8637S      品牌：CST       原厂货号：8637S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

RRM1 (D12F12) XP® Rabbit mAb能够检测内源性RRM1总蛋白。该单克隆抗体是由合成的人源的针对RRM1蛋白羧基末端的肽段免疫动物生产的。核糖核苷酸还原酶能够催化脱氧核苷酸三磷酸（dNTPs）合成中的限速步骤。调节性的M1亚基（RRM1）出现在整个细胞分裂周期，但在静止期细胞中下调（1）。研究表明，RRM1参与肿瘤发生和肿瘤进展，并且其表达与非小细胞肺癌化疗抵抗相关（2-4）。

1. Mann, G.J. et al. (1988) Cancer Res 48, 5151-6.
2. Zheng, Z. et al. (2007) N Engl J Med 356, 800-8.
3. Ceppi, P. et al. (2006) Ann Oncol 17, 1818-25.
4. Bepler, G. et al. (2006) J Clin Oncol 24, 4731-7.

原厂资料：

Specificity / Sensitivity

RRM1 (D12F12) XP® Rabbit mAb recognizes endogenous levels of total RRM1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human RRM1 protein.

Background

Ribonucleotide reductase catalyzes the rate-limiting step in the synthesis of deoxynucleotide triphosphates (dNTPs). The regulatory M1 subunit (RRM1) is present throughout the cell division cycle, but downregulated in quiescent cells (1). Research studies have demonstrated that RRM1 is involved in carcinogenesis and tumor progression, and its expression is correlated with resistance to chemotherapy in non-small cell lung cancer (2-4).

1. Mann, G.J. et al. (1988) Cancer Res 48, 5151-6.
2. Zheng, Z. et al. (2007) N Engl J Med 356, 800-8.
3. Ceppi, P. et al. (2006) Ann Oncol 17, 1818-25.
4. Bepler, G. et al. (2006) J Clin Oncol 24, 4731-7.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.