Nanog Antibody (Mouse Specific)

产品编号：CST-8600S 品牌：Cell Signaling Technology 原厂货号：8600S
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

100 ul

运保温度:

–20°C

到货周期：

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描述：

Nanog抗体（小鼠特异）识别小鼠内源的总Nanog蛋白。多克隆抗体是通过一种合成的肽段去免疫动物产生。这种合成的肽段与包围于鼠源Nanog 蛋白邻近羧基末端的氨基酸序列一致，抗体由蛋白A和肽段亲和层析技术纯化得到。Nanog是一个含有同源结构域的转录因子，对于维持胚胎干细胞的多潜能性和自我更新非常重要（1）。Nanog的表达由包括Sox2和关键多潜能性调控因子Oct-4在内的调控网络调控（1）。近来对于体细胞重编程的研究进展主要通过整合包含nanog, Oct-4, Sox2, KLF4, c-Myc和 LIN28等转录因子病毒表达来实现 (2,3).

原厂资料：

Specificity / Sensitivity

Nanog Antibody (Mouse Specific) recognizes endogenous levels of total mouse nanog protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse nanog protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Nanog is a homeodomain-containing transcription factor that is essential for the maintenance of pluripotency and self renewal in embryonic stem cells (1). Nanog expression is controlled by a network of factors including Sox2 and the key pluripotency regulator Oct-4 (1). Recent advances in somatic cell reprogramming have utilized viral expression of combinations of transcription factors including nanog, Oct-4, Sox2, KLF4, c-Myc, and LIN28 (2,3).

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.