IMP1 (D33A2) Rabbit mAb

• 产品编号：CST-8482S      品牌：CST       原厂货号：8482S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

IMP1 (D33A2) Rabbit mAb能够检测内源性的 IMP1 总蛋白水平。该单克隆抗体经由合成的围绕人IMP1蛋白近氨基端的氨基酸肽段免疫动物而生产的。胰岛素类生长因子-II mRNA结合蛋白 (IMPs)属于zipcode结合蛋白家族成员(1,2)。已经鉴定出来该家族的三个成员为IMP1, IMP2和IMP3 (1,2)。它们包括两个RNA识别序列和四个K 同源结构域，并且研究发现他们在mRNA定位、降解和翻译控制中都有作用(1,2)。研究发现这些蛋白涉及了多种生理和病理过程，例如生长发育(3)、睾丸肿瘤(4)和黑色素瘤 (5)。

1. Nielsen, F.C. et al. (2002) J Cell Sci 115, 2087-97.
2. Nielsen, J. et al. (2003) Biochem J 376, 383-91.
3. Hansen, T.V. et al. (2004) Mol Cell Biol 24, 4448-64.
4. Hammer, N.A. et al. (2005) Reproduction 130, 203-12.
5. Pryor, J.G. et al. (2008) Mod Pathol 21, 431-7.

原厂资料：

Specificity / Sensitivity

IMP1 (D33A2) Rabbit mAb recognizes endogenous levels of total IMP1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human IMP1 protein.

Background

Insulin-like growth factor-II mRNA-binding proteins (IMPs) belong to a family of zipcode-binding proteins (1,2). Three members of this family, IMP1, IMP2, and IMP3, have been identified (1,2). They contain two RNA recognition motifs, four K homology domains, and were found to function in mRNA localization, turnover, and translation control (1,2). Research studies have implicated these proteins in a variety of physiological and pathological processes, such as growth and development (3), testicular neoplasia (4), and melanocytic neoplasia (5).

1. Nielsen, F.C. et al. (2002) J Cell Sci 115, 2087-97.
2. Nielsen, J. et al. (2003) Biochem J 376, 383-91.
3. Hansen, T.V. et al. (2004) Mol Cell Biol 24, 4448-64.
4. Hammer, N.A. et al. (2005) Reproduction 130, 203-12.
5. Pryor, J.G. et al. (2008) Mod Pathol 21, 431-7.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.